Parameters

Caffeine

BCG

Treatment groups

RPMP

DBR

MIX

AUC(0 − t) (mg* h/l)

57.40 ± 15.92

34.03 ± 7.25^**

75.68 ± 18.54^*

66.85 ± 32.12

AUC(0 −∞) (mg* h/l)

60.03 ± 17.53

34.67 ± 7.49^**

95.84 ± 32.58^**

88.13 ± 59.83

MRT(0 − t) (h)

2.94 ± 0.75

2.14 ± 0.32^*

4.02 ± 0.76^*

3.21 ± 1.272

MRT(0 −∞) (h)

3.44 ± 1.18

2.28 ± 0.35

6.87 ± 3.36

5.67 ± 4.30

t_1/2 (h)

2.17 ± 0.24

1.28 ± 0.32^*

4.60 ± 0.38^*

2.84 ± 0.56

CL (l/h/kg)

0.18 ± 0.074

0.30 ± 0.06^**

0.11 ± 0.03^*

0.16 ± 0.091

Vz (L/Kg)

0.51 ± 0.17

0.54 ± 0.17

0.70 ± 0.28^*

0.58 ± 0.094